This article focuses on exploring the essential role of political prisoners in peacemaking and ceasefire agreements. It discusses the participation of political prisoners in conflict resolution processes and their influence on political initiatives to address situations of conflicts and politically motivated violence. The overall objectives of the article are to demonstrate that political prisoners are central to any successful peacemaking process, and to argue for the importance of inclusive engagement of all parties to the conflict in peace talks and negotiations. Hence, the article explores the contribution of Northern Ireland’s political prisoners to peacemaking efforts and the subsequent Good Friday Agreement. It starts with a brief history of political prisoners in Northern Ireland, and then examines their involvement in mediating ceasefires and providing their political leaders with the support and legitimacy they sought in reaching a peace agreement. The article ends with sharing lessons about political prisoners and their relationship to successful peace processes.